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Scientific papers
and resources (sorted
alphabetically by title)
(sorted by date)
A Fresh Look at BSE - Chesebro
Science - September 24, 2004
A newly identified type of scrapie agent can
naturally infect sheep with resistant PrP genotypes - Le Dur, et al.
Proceedings of the National Academy of
Sciences - October 20, 2005 (pdf)
A Protease Resistant PrP Isoform Is Present In
Urine of Animals and Humans Affected with Prion Diseases - Shaked, et al.
Journal of Biological Chemistry - June
21, 2001 (pdf)
Abnormal Prion Protein in Ectopic Lymphoid
Tissue in a Kidney of an Asymptomatic White-tailed Deer Experimentally
Inoculated with the Agent of Chronic Wasting Disease - Hamir, et al.
Abundant PrP(CWD) in tonsil from mule deer with preclinical chronic wasting
disease - O'Rourke, et al.
Journal
of Veterinary Diagnostic Investigation - July 2003 (abstract)
Accumulation of Pathological Prion Protein PrPSc in the
Skin of Animals with Experimental and Natural Scrapie - Thomzig, et al.
PLoS Pathogens - May 25, 2007 (pdf)
Adaptation of the bovine spongiform
encephalopathy agent to primates and comparison with Creutzfeldt-Jakob
disease: Implications for human health - Lasmezas, et al.
Proceedings of the National Academy of Sciences -
March 27, 2001
(pdf)
Additional Cases of Chronic Wasting Disease in Imported Deer in Korea - Kim, et al.
Journal of Veterinary Medical Science - 2005
Alzheimer-type neuropathology in a 28 year old patient
with iatrogenic Creutzfeldt-Jakob disease after dural grafting - Preusser et
al.
Journal of Neurology, Neurosurgery, and
Psychiatry - 2006 (abstract)
Amyloid plaques in spongiform encephalopathy of
mule deer - Bahmanyar , et al.
Journal of Comparative Pathology -
January 1985
Analysis of unusual accumulation of
Creutzfeldt-Jakob disease cases in Orava and Liptov regions (northern Slovak
focus) 1983-2000 - Mad'ar, et al.
Central European Journal of Public
Health - March 2003 (abstract)
Atypical Case of
Bovine Spongiform Encephalopathy in an East-Flemish Cow
in Belgium - De Bosschere, et al.
The International
Journal of Applied Research
in Veterinary
Medicine - 2004
Atypical Proteinase K-Resistant Prion Protein
(PrPres) Observed in an Apparently Healthy 23-Month-Old Holstein Steer -
Yamakawa, et al.
Japanese Journal of Infectious Diseases
- 2003 (pdf)
Best
Management Practices for Handling Suspect Biosafety Level 2 Animal
Transmissible Spongiform Encephalopathy (TSE) Diagnostic Samples (Scrapie,
Chronic Wasting Disease and Transmissible Mink
Encephalopathy) in Animal Health Laboratories
American Association of Veterinary Laboratory Diagnosticians - February 18,
2004
Biosafety in Microbiological and Biomedical Laboratories
- Fourth Edition
U.S. Department of
Health and Human Services Public Health Service - Centers for Disease
Control and Prevention -
April 1999 (pdf)
Bovine Spongiform Encephalopathy and Variant
Creutzfeldt-Jakob Disease: Background, Evolution, and Current Concerns -
Brown, et al.
Emerging Infectious Diseases - 2001 (pdf)
Bovine spongiform encephalopathy, chronic
wasting disease, scrapie, and the threat to humans from prion disease
epizootics - Bosque
Current neurology and neuroscience
reports - November 2002 (abstract)
Bovine spongiform encephalopathy infectivity in
greater kudu (Tragelaphus strepsiceros) - Cunningham, et al.
Emerging Infectious Diseases - June 2004
(abstract)
Bovine Spongiform Encephalopathy: what is
"Atypical BSE" and can we detect it? - Richt
Animal Health Research Reviews -
accepted for publication October 17, 2006 (abstract)
Brain biopsy in dementia
- Warren, et al.
Brain - A journal of Neurology - May 18, 2005 (abstract)
BSE prions propagate as either variant CJD-like or
sporadic CJD-like prion strains in transgenic mice expressing human prion
protein - Asante, et al.
The EMBO Journal - 2002 (pdf)
BSE: the final resting
place - Brown
Lancet - April 18, 1998
Cases of scrapie with unusual features in Norway and
designation of a new type, Nor98 - Benestad, et al.
The Veterinary Record - August 16, 2003
(abstract)
Characterization of Thermodynamic Diversity
between Transmissible Spongiform Encephalopathy Agent Strains and Its
Theoretical Implications - Somerville, et al.
Journal of Biological Chemistry - March
29, 2002 (pdf)
Characterization of two
distinct prion strains derived from bovine spongiform
encephalopathy transmissions to inbred mice - Lloyd, et
al.
Journal of General
Virology - 2004 (pdf)
Chronic
Wasting Disease - Williams
Veterinary Pathology - 2005
(pdf)
Chronic Wasting Disease and Potential Transmission to Humans - Belay, et al.
Emerging Infectious Diseases - June 2004
(pdf)
Chronic wasting disease and tissues that might carry a
risk for human food and animal feed chains
European
Commission - Scientific Steering Committee - 2003 (pdf)
Chronic wasting disease in deer
and
elk: a critique of current models and
their application - Schauber & Woolf
Wildlife Society Bulletin
- 2003 (pdf)
Chronic
Wasting Disease in Deer and Elk: Scientific Facts and Findings - Salman
Journal of
Veterinary Medical Science - 2003 (pdf)
Chronic Wasting Disease in Mule
Deer: Disease Dynamics and Control - Gross & Miller
Journal of Wildlife Management -
2001 (pdf)
Chronic Wasting Disease of Elk: Transmissibility to Humans Examined by
Transgenic Mouse Models - Kong, et al.
The Journal of Neuroscience - August 31,
2005 (pdf)
Chronic Wasting Disease of Elk and Deer and Creutzfeldt-Jakob Disease:
Comparative Analysis of the Scrapie Prion Protein - Xie, et al.
(Pre-publication
copy) -
2006
(pdf)
Clinical
findings in two cases of atypical scrapie in sheep: a case report - Konold,
et al.
BMC Veterinary Research - February 13,
2007 (pdf)
Clinical presentation and
pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with
blood transfusion: a case report - Wroe, et al.
Lancet - December 9, 2006 (abstract)
"Clusters" of CJD in Slovakia: the first laboratory evidence of scrapie -
Mitrova, et al.
European Journal of Epidemiology -
September 1991
Coexistence of
Creutzfeldt-Jakob disease and Alzheimer's disease in the same patient -
Brown, et al.
Neurology - February 1990 (abstract)
Coincident Scrapie Infection and Nephritis Lead to Urinary Prion Excretion -
Seeger, et al.
Science -
October 14, 2005 (abstract)
Colorado
Surveillance Program for Chronic Wasting Disease Transmission to Humans -
Anderson, et al.
Archives of Neurology - March 2007
(abstract)
Comparison of Abnormal Prion Protein Glycoform Patterns
from Transmissible Spongiform Encephalopathy Agent-Infected Deer, Elk,
Sheep, and Cattle - Race, et al.
Journal of Virology - December 2002
(pdf)
Comparative Analysis of Scrapie Agent
Inactivation Methods - Ernst and Race
Journal of Virological Methods - 1993
(pdf)
Concomitant Creutzfeldt-Jakob and Alzheimer diseases -
Powers, et al.
Acta Neuropathologica - 1991 (pdf)
Contaminated dental instruments - Smith, et al.
Journal of Hospital Infection - July
2002 (abstract)
Creutzfeldt-Jakob disease and inclusion body
myositis: Abundant disease-associated prion protein in muscle - Kovacs, et
al.
Annals
of Neurology - December 30, 2003 (abstract)
Creutzfeldt-Jakob Disease in Unusually Young
Patients Who Consumed Venison - Belay, et al.
Archives of Neurology - October 2001
(pdf)
Creutzfeldt-Jakob Disease Surveillance and Diagnosis -
Belay, et al.
Clinical Infectious Diseases - September
15, 2005 (pdf)
Decontamination studies with the agents of
bovine spongiform encephalopathy and scrapie - Taylor, et al.
Archives of Virology - 1994 (abstract)
Detection and
Localization of PrPSc in the Skeletal Muscle of Patients with
Variant, Iatrogenic, and Sporadic Forms of Creutzfeldt-Jakob Disease -
Peden, et al.
American
Journal of Pathology - 2006 (abstract)
Detection of prions in blood - Castilla, et al.
Nature Medicine - August 28, 2005
(abstract)
Different prion disease phenotypes result from
inoculation of cattle with two temporally separated sources of sheep scrapie
from Great Britain - Konold, et al.
BMC Veterinary Research - October 17,
2006 (pdf)
Discharges of Laboratory Waste to Publicly-Owned
Treatment Works (POTWs) - DRAFT
Industrial Pretreatment Program - US
Environmental Protection Agency Region 8 - May 4, 2003 (pdf)
Disinfection studies with two strains of
mouse-passaged scrapie agent. Guidelines for Creutzfeldt-Jakob and related
agents - Kimberlin,
et al.
Journal of the Neurological Sciences -
June 1983 (abstract)
Effect of chemicals, heat, and histopathologic
processing on high-infectivity hamster-adapted scrapie virus - Brown, et al.
Journal of Infectious Diseases -
May 1982 (abstract)
EFFICIENT IN VITRO AMPLIFICATION OF CHRONIC
WASTING DISEASE PrPRES - Kurt, et al.
Journal of Virology - June 6, 2007
(abstract)
Environmental
Sources of Prion Transmission in Mule Deer - Miller, et al.
Emerging Infectious Diseases - June 2004
(pdf)
Epidemiological observations on spongiform
encephalopathies in captive wild animals in the British Isles - Kirkwood &
Cunningham
The Veterinary Record - September 24,
1994 (abstract)
Epidemiology of chronic wasting disease in free-ranging mule deer: spatial,
temporal, and demographic influences on observed prevalence patterns -
Miller and Conner
Journal of Wildlife Diseases - 2005
Evaluation of a Preclinical Blood Test for Scrapie in Sheep Using
Immunocapillary Electrophoresis - Jackman, et al.
Journal of AOAC International - May 2006
(abstract)
Evidence of a molecular barrier limiting
susceptibility of humans, cattle and sheep to chronic wasting disease - Raymond, et al.
EMBO Journal - 2000
(pdf)
Evidence That
Transmissible Mink Encephalopathy Results from Feeding Infected Cattle -
Marsh & Hartsough
Proceedings of the Fourth International
Scientific Congress in Fur Animal Production - August 21-28, 1988
(pdf)
Experimental Second Passage of Chronic
Wasting Disease (Cwd-Mule Deer) Agent to Cattle - Hamir, et al.
Journal Of Comparative Pathology
- 2006 (pdf)
Experimental transmission of chronic wasting
disease agent from mule deer to cattle by the intracerebral route - Hamir,
et al.
Journal of Veterinary Diagnostic Investigation - May 2005 (abstract)
Experimental transmission of
transmissible mink encephalopathy (TME) to cattle by
intracerebral inoculation - Hamir, et al.
4th International
Veterinary Vaccines and Diagnostics Conference - June
25, 2006 (abstract)
Extraneural Prion
Neuroinvasion without Lymphoreticular System Infection -
Bartz, et al.
Journal of Virology
- September 2005 (pdf)
FINAL OPINION AND REPORT ON : A TREATMENT OF
ANIMAL WASTE BY MEANS OF HIGH TEMPERATURE (150°C, 3 HOURS) AND HIGH PRESSURE
ALKALINE HYDROLYSIS.
European Commission - Scientific
Steering Committee - April 10, 2003 (pdf)
First and Second Cattle Passage of Transmissible
Mink Encephalopathy by Intracerebral Inoculation - Hamir, et al.
Veterinary Pathology - 2006 (abstract)
Horizontal prion transmission in mule deer - Miller & Williams
The gathering of deer during winter may foster the spread of chronic
wasting disease.
Nature - September 4, 2003 (pdf)
Identification and Characterization of U.S. BSE
Cases - Hall, et al.
Prion Diseases of Domestic Livestock. p.
25. - May 28, 2006 (abstract)
Identification of a second bovine amyloidotic spongiform
encephalopathy: Molecular similarities with sporadic Creutzfeldt-Jakob
disease - Casalone, et al.
Proceedings of the National Academy of
Sciences - March 2, 2004 (pdf)
Inactivation of prions by physical and chemical
means - Taylor
Journal of Hospital Infection - December
1999 (abstract)
Inactivation of the 22A strain of scrapie agent by
autoclaving in sodium hydroxide - Taylor, et al.
Veterinary Microbiology - November 1997
(abstract)
Inactivation of the BSE agent - Taylor
Comptes rendus biologies - January 2002
(abstract)
Inactivation of Transmissible Degenerative Encephalopathy Agents: A Review -
D.M. Taylor
Veterinary Journal - 2000 (pdf)
Inactivation of Transmissible Spongiform
Encephalopathy (Prion) Agents by Environ LpH - Race and Raymond
Journal of Virology - February 2004
(pdf)
Infectious agent of sheep scrapie may persist in
the environment for at least 16 years - Georgsson, et al.
Journal of General Virology - December
2006 (abstract)
Infectious Prions in the Saliva and Blood of Deer with Chronic Wasting
Disease - Mathiason, et al.
Science - October 5, 2006
Inhibition of Protease-Resistant
Prion
Protein Formation in a Transformed Deer Cell Line Infected with Chronic
Wasting Disease - Raymond, et al.
Journal of Virology - January 2006
Insoluble Aggregates and Protease-resistant Conformers of
Prion Protein in Uninfected Human Brains - Yuan, et al.
Journal of Biological Chemistry -
November 17, 2006 (abstract)
Interspecies Transmission of Chronic Wasting
Disease Prions to Squirrel Monkeys (Saimiri sciureus) - Marsh, et al.
Journal
of Virology - November 2005 (pdf)
Intracerebral transmission of scrapie to cattle
- Cutlip, et al.
Journal of Infectious Diseases - April
1994 (pdf)
Laboratory Security and Emergency Response Guidance for
Laboratories Working with Select Agents
Centers for Disease Control and
Prevention - December 6, 2002 (pdf)
Levels of Abnormal Prion Protein in Deer and Elk with
Chronic Wasting Disease - Race, et al.
Emerging Infectious Diseases - June 2007
(pdf)
Long-Term Subclinical Carrier State Precedes
Scrapie Replication and Adaptation in a Resistant Species: Analogies to
Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease in
Humans - Race, et al.
Journal of Virology - November 2001
(pdf)
Low
frequency of PrP genotype 225SF among free-ranging mule deer (Odocoileus
hemionus) with chronic wasting
disease - Jewell, et al.
Journal of General Virology - May 27,
2005 (pdf)
Natural transmission of BSE between sheep within an
experimental flock - Bellworthy, et al.
Veterinary Record - August 13, 2005
(abstract)
New studies on the heat
resistance of hamster-adapted scrapie agent: Threshold
survival after ashing at 600°C suggests an inorganic
template of replication - Brown, et al.
Proceedings of the National Academy of Sciences - March
28, 2000 (pdf)
Novel methods for disinfection of prion-contaminated
medical devices - Fichet, et al.
Lancet - 2004 (pdf)
On the Question of Sporadic or Atypical Bovine Spongiform
Encephalopathy and Creutzfeldt-Jakob Disease - Brown, et al.
Emerging Infectious Diseases - Centers
for Disease Control and Prevention - December 2006 (pdf)
Opinion on The Safety of Human-derived Products with
regard to Variant Creutzfeldt-Jakob Disease
SCIENTIFIC COMMITTEE ON EMERGING AND
NEWLY IDENTIFIED HEALTH RISKS - European Commision - May 11, 2006 (pdf)
Opinion on the use of small incinerators for BSE
risk reduction
European Commission - Scientific
Steering Committee - January 16-17, 2003 (pdf)
Oral transmission and early lymphoid tropism of chronic wasting disease
PrPres in mule deer fawns (Odocoileus hemionus) -
Sigurdson, et al.
Journal of General Virology - 1999 (pdf)
Oral Transmission of Chronic Wasting Disease
in Captive Shira’s Moose - Kreeger, et al.
Oral transmission of kuru, Creutzfeldt-Jakob
disease, and scrapie to nonhuman primates - Gibbs, et al.
Journal of Infectious Diseases - August
1980 (abstract)
Patterns of PrPCWD accumulation during the
course of CWD infection in orally inoculated mule deer (Odocoileus hemionus)
- Fox, et al.
Journal of General Virology - November
2006 (abstract)
Pathology of Variant CreutzfeIdt-Jakob Disease -
Ironside
International Symposium of Prion
Diseases, Sendai, Japan - October 31 - November 2, 2004
Polymorphisms in the prion precursor functional gene but not the pseudogene
are associated with susceptibility to chronic wasting disease in
white-tailed deer - O'Rourke, et al.
Journal of General Virology - 2004 (pdf)
Position
statement on methods to evaluate decontamination technologies for
surgical instruments
Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous
patient - Peden, et al.
Lancet - August 7, 2004 (abstract)
Predicting susceptibility and incubation time of
human-to-human transmission of vCJD - Bishop, et al.
Lancet Neurology - May 2006 (abstract)
Presymptomatic Detection of Prions in Blood - Saa, et al.
Science - July 7, 2006
(pdf)
Prion Diseases: from transmission experiments to
structural biology — still searching for the cause - Liberski & Brown
Folia Neuropathologica - 2004 (pdf)
Prion Infection of Mucosal Tissue - Bessen,
et al.
2nd International
Chronic Wasting Disease Symposium- July 12, 2005
Prion Infection of
Skeletal Muscle Cells and Papillae in the Tongue -
Mulcahy,
et al.
Journal
of Virology - July 2004
Prion
protein in cardiac muscle of elk (Cervus elaphus nelsoni) and white-tailed
deer (Odocoileus virginianus) infected with chronic wasting disease
- Jewell, et al.
Journal of General Virology - November
2006
(abstract)
Prion-induced amyloid heart disease with high blood infectivity in
transgenic mice - Trifilo, et al.
Science - July 7, 2006
(abstract)
Prions - Prusiner (Nobel Lecture)
Proceedings of the National Academy of Sciences -
November 10, 1998
(pdf)
Prions
Adhere to Soil Minerals and Remain Infectious - Johnson, et al.
www.plospathogens.org - April 2006
(pdf)
Prions in skeletal muscle - Bosque, et al.
Proceedings of the National Academy of Sciences - March
19, 2002 (pdf)
Prions in Skeletal Muscles of Deer with Chronic Wasting
Disease - Angers, et al.
www.sciencexpress.org - January 26, 2006
(pdf)
Prions in Skeletal
Muscles of Deer with Chronic Wasting Disease - Angers,
et al. (Supporting Online
Material)
www.sciencexpress.org - January 26, 2006 (pdf)
Protease-Resistant Human Prion Protein and Ferritin Are Cotransported across
Caco-2 Epithelial Cells: Implications for Species Barrier in Prion Uptake
from the Intestine - Mishra, et al.
The Journal of Neuroscience - December
15, 2004 (pdf)
RELATIVE VULNERABILITY OF CHRONIC WASTING
DISEASE INFECTED MULE DEER TO VEHICLE COLLISIONS - Krumm, et al.
Journal of Wildlife Diseases - July 2005
(pdf)
Risk of oral infection with bovine spongiform
encephalopathy agent in primates - Lasmézas, et al.
Lancet - February 26, 2005 (abstract)
Risks of transmission of
variant Creutzfeldt-Jakob disease by blood transfusion - Peden, et al.
Folia Neuropathologica - 2005 (pdf)
Scrapie Agent (Strain 263K) Can Transmit Disease via the
Oral Route after Persistence in Soil over Years - Seidel, et al.
www.plosone.org
- May 2007 (pdf)
Scrapie Infectivity and Proteinase K–Resistant Prion
Protein in Sheep Placenta, Brain, Spleen, and Lymph Node: Implications for
Transmission and Antemortem Diagnosis - Race, et al.
The Journal of Infectious Diseases -
1998 (pdf)
Sheep consumption: a possible source of
spongiform encephalopathy in humans - Davanipour, et al.
Neuroepidemiology - 1985
Sheep-passaged BSE agent exhibits altered
patho-biological properties -
Espinosa, et al.
Journal of Virology - November 1, 2006
(abstract)
Species-barrier-independent prion replication in
apparently resistant species - Hill, et al.
Proceedings of the National Academy of
Sciences - August 29, 2000 (pdf)
Spongiform Encephalopathy in a Miniature Zebu -
Seuberlich, et al.
Emerging Infectious Diseases -
www.cdc.gov/eid - December 2006 (pdf)
Strain fidelity of chronic wasting disease upon
murine adaptation - Sigurdson et al.
Journal of Virology - October 4, 2006
(abstract)
Surface decontamination of surgical instruments:
an ongoing dilemma - Murdoch, et al.
Journal of Hospital Infection - August
2006
Survival of scrapie virus after 3 years'
interment - Brown & Gajdusek
Lancet - February 2, 1991 (abstract)
The coexistence of Alzheimer's disease and
Creutzfeldt-Jakob disease in a patient with dementia of long duration -
Muramoto, et al.
Acta Neuropathologica - 1992 (pdf)
The Host Range of Chronic Wasting Disease Is Altered on
Passage in Ferrets - Bartz, et al.
Virology - November 25, 1998
The
most infectious prion protein particles - Silveira, et al.
Nature
- September 8, 2005 (abstract)
The
physical basis of how prion conformations determine strain phenotypes -
Tanaka, et al.
Nature
- June 28, 2006 (abstract)
Thermostability of mouse-passaged BSE and
scrapie is independent of host PrP genotype implications for the nature of
the causal
agents - Taylor, et al.
Journal of General Virology - 2002 (pdf)
Transmissible Encephalopathies: Speculations and Realities - Manuelidis
Viral Immunology
- June 2003 (abstract)
Transmission and Adaptation of Chronic Wasting Disease to
Hamsters and Transgenic Mice: Evidence for Strains - Raymond, et al.
Journal of Virology - April 2007
(abstract)
Transmission of BSE by blood transfusion in sheep - Houston, et al.
Lancet - 2000
Transmission of chronic wasting disease agent of mule
deer (CWD**md) to Suffolk sheep by intracerebral route - Hamir, et al.
European Society of Veterinary Pathology
24th Annual Meeting. Paper No. P63. p. 171-172 - August 31, 2006 (abstract)
Transmission of Creutzfeldt-Jakob disease to a
chimpanzee by electrodes contaminated during neurosurgery - Gibbs, et al.
Journal of neurology, neurosurgery, and
psychiatry - June 1994
Transmission of Elk and Deer Prions to
Transgenic Mice - Tamgüney, et al.
Journal of Virology - September 2006
(pdf)
Transmission of prion diseases by blood transfusion - Hunter, et al.
Journal of General Virology - July 16,
2000 (pdf)
Ultra-efficient Replication of Infectious Prions by
Automated Protein Misfolding Cyclic Amplification - Saa, et al.
Journal of Biological Chemistry -
November 17, 2006 (abstract)
Ultra-high-pressure inactivation of prion
infectivity in processed meat: A practical method to prevent human infection
- Brown, et al.
Proceedings of the National Academy of Sciences - May
13, 2003 (pdf)
UNCONVENTIONAL VIRUSES AND THE ORIGIN AND
DISAPPEARANCE OF KURU - Gajdusek
Nobel Lecture - December 13, 1976 (pdf)
Urine from Scrapie-Infected
Hamsters Comprises Low Levels of Prion Infectivity -
Kariv-Inbal, et al.
Neurodegenerative Diseases - September
2006 (abstract)
Use of capillary
electrophoresis and fluorescent labeled peptides to detect the abnormal
prion protein in the blood of animals that are infected with a transmissible
spongiform encephalopathy - Schmerr, et al.
Journal
of Chromatography - 1999 (abstract)
Variant CJD (vCJD) and Bovine Spongiform
Encephalopathy (BSE): 10 and 20 years on: part 1 - Bradley, et al.
Folia Neuropathologica - 2006 (pdf)
Variant CJD (vCJD) and Bovine Spongiform
Encephalopathy (BSE): 10 and 20 years on: part 2 - Collee, et al.
Folia Neuropathologica - 2006 (pdf)
Virus-Like Sensitivity of the Scrapie Agent to Heat
Inactivation - Rohwer
Science - February 1984 (pdf)
WHO guidelines on tissue infectivity
distribution in transmissible spongiform encephalopathies
World Health Organization - 2006 (pdf)