-
-
Prion-induced amyloid heart
disease with high blood infectivity in transgenic mice.
Trifilo MJ,
Yajima T,
Gu Y,
Dalton N,
Peterson KL,
Race RE,
Meade-White K,
Portis JL,
Masliah E,
Knowlton KU,
Chesebro B,
Oldstone MB.
Viral-Immunobiology Laboratory, Departments of Molecular
and Integrative Neurosciences and Infectology, Scripps
Research Institute, La Jolla, CA 92037, USA.
We investigated extraneural manifestations in
scrapie-infected transgenic mice expressing prion
protein lacking the glycophosphatydylinositol membrane
anchor. In the brain, blood, and heart, both abnormal
protease-resistant prion protein (PrPres) and prion
infectivity were readily detected by immunoblot and by
inoculation into nontransgenic recipients. The titer of
infectious scrapie in blood plasma exceeded 10(7) 50%
infectious doses per milliliter. The hearts of these
transgenic mice contained PrPres-positive amyloid
deposits that led to myocardial stiffness and cardiac
disease.
PMID: 16825571 [PubMed - in process]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=16825571
|