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Lancet. 1991 Feb 2;337(8736):269-70. |
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Survival of scrapie virus after
3 years' interment
Brown P, Gajdusek DC.
Laboratory of CNS Studies, National Institute of
Neurological Disorders and Stroke, National Institutes of
Health, Bethesda, Maryland 20892.
Supernatant fluid from a scrapie-infected hamster brain
homogenate was mixed with soil, packed into perforated petri
dishes that were then embedded within soil-containing pots,
and buried in a garden for 3 years. Between 2 and 3 log
units of the input infectivity of nearly 5 log units
survived this exposure, with little leaching of virus into
deeper soil layers. These results have implications for
environmental contamination by scrapie and by similar
agents, including those of bovine spongiform encephalopathy
and Creutzfeldt-Jakob disease.
PMID: 1671114 [PubMed - indexed for MEDLINE]
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