Scientific papers and resources (sorted by date) (sorted alphabetically by title)
EFFICIENT IN VITRO AMPLIFICATION OF CHRONIC WASTING DISEASE PrPRES - Kurt, et al.
Journal of Virology - June 6, 2007 (abstract) NEW
Levels of Abnormal Prion Protein in Deer and Elk with Chronic Wasting Disease - Race, et al.
Emerging Infectious Diseases - June 2007 (pdf) NEW
Accumulation of Pathological Prion Protein PrPSc in the Skin of Animals with Experimental and Natural Scrapie - Thomzig, et al.
PLoS Pathogens - May 25, 2007 (pdf) NEW
Scrapie Agent (Strain 263K) Can Transmit Disease via the Oral Route after Persistence in Soil over Years - Seidel, et al.
www.plosone.org - May 2007 (pdf) NEW
Transmission and Adaptation of Chronic Wasting Disease to Hamsters and Transgenic Mice: Evidence for Strains - Raymond, et al.
Journal of Virology - April 2007 (abstract)
Colorado Surveillance Program for Chronic Wasting Disease Transmission to Humans - Anderson, et al.
Archives of Neurology - March 2007 (abstract)
Clinical findings in two cases of atypical scrapie in sheep: a case report - Konold, et al.
BMC Veterinary Research - February 13, 2007 (pdf)
Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion: a case report - Wroe, et al.
Lancet - December 9, 2006 (abstract)
Spongiform Encephalopathy in a Miniature Zebu - Seuberlich, et al.
Emerging Infectious Diseases - www.cdc.gov/eid - December 2006 (pdf)
Infectious agent of sheep scrapie may persist in
the environment for at least 16 years - Georgsson, et al.
Journal of General Virology - December 2006 (abstract)
On the Question of Sporadic or Atypical Bovine Spongiform Encephalopathy and Creutzfeldt-Jakob Disease - Brown, et al.
Emerging Infectious Diseases - Centers for Disease Control and Prevention - December 2006 (pdf)
Insoluble Aggregates and Protease-resistant Conformers of Prion Protein in Uninfected Human Brains - Yuan, et al.
Ultra-efficient Replication of Infectious Prions by Automated Protein Misfolding Cyclic Amplification - Saa, et al.
Journal of Biological Chemistry - November 17, 2006 (abstract)
Sheep-passaged BSE agent exhibits altered
patho-biological properties -
Journal of Virology - November 1, 2006 (abstract)
Patterns of PrPCWD accumulation during the course of CWD infection in orally inoculated mule deer (Odocoileus hemionus) - Fox, et al.
Journal of General Virology - November 2006 (abstract)
Prion protein in cardiac muscle of elk (Cervus elaphus nelsoni) and white-tailed deer (Odocoileus virginianus) infected with chronic wasting disease - Jewell, et al.
Journal of General Virology - November 2006 (abstract)
Bovine Spongiform Encephalopathy: what is "Atypical BSE" and can we detect it? - Richt
Animal Health Research Reviews - accepted for publication October 17, 2006 (abstract)
Different prion disease phenotypes result from inoculation of cattle with two temporally separated sources of sheep scrapie from Great Britain - Konold, et al.
BMC Veterinary Research - October 17, 2006 (pdf)
Infectious Prions in the Saliva and Blood of Deer with Chronic Wasting Disease - Mathiason, et al.
Strain fidelity of chronic wasting disease upon murine adaptation - Sigurdson et al.
Journal of Virology - October 4, 2006 (abstract)
Transmission of Elk and Deer Prions to Transgenic Mice - Tamgüney, et al.
Journal of Virology - September 2006 (pdf)
Urine from Scrapie-Infected Hamsters Comprises Low Levels of Prion Infectivity - Kariv-Inbal, et al.
Neurodegenerative Diseases - September 2006 (abstract)
Position statement on methods to evaluate decontamination technologies for surgical instruments
Transmission of chronic wasting disease agent of mule deer (CWD**md) to Suffolk sheep by intracerebral route - Hamir, et al.
Surface decontamination of surgical instruments: an ongoing dilemma - Murdoch, et al.
Journal of Hospital Infection - August 2006
Presymptomatic Detection of Prions in Blood - Saa, et al.
Prion-induced amyloid heart disease with high blood infectivity in transgenic mice - Trifilo, et al.
Science - July 7, 2006 (abstract)
Oral Transmission of Chronic Wasting Disease in Captive Shira’s Moose - Kreeger, et al.
Journal of Wildlife Diseases - July 2006 (abstract)
The physical basis of how prion conformations determine strain phenotypes - Tanaka, et al.
Nature - June 28, 2006 (abstract)
Experimental transmission of transmissible mink encephalopathy (TME) to cattle by intracerebral inoculation - Hamir, et al.
4th International Veterinary Vaccines and Diagnostics Conference - June 25, 2006 (abstract)
Identification and Characterization of U.S. BSE Cases - Hall, et al.
Prion Diseases of Domestic Livestock. p. 25. - May 28, 2006 (abstract)
Opinion on The Safety of Human-derived Products with regard to Variant Creutzfeldt-Jakob Disease
Evaluation of a Preclinical Blood Test for Scrapie in Sheep Using Immunocapillary Electrophoresis - Jackman, et al.
Journal of AOAC International - May 2006 (abstract)
Predicting susceptibility and incubation time of human-to-human transmission of vCJD - Bishop, et al.
Lancet Neurology - May 2006 (abstract)
Prions Adhere to Soil Minerals and Remain Infectious - Johnson, et al.
www.plospathogens.org - April 2006 (pdf)
Prions in Skeletal Muscles of Deer with Chronic Wasting Disease - Angers, et al.
www.sciencexpress.org - January 26, 2006 (pdf)
Prions in Skeletal Muscles of Deer with Chronic Wasting Disease - Angers, et al. (Supporting Online Material)
www.sciencexpress.org - January 26, 2006 (pdf)
Inhibition of Protease-Resistant Prion Protein Formation in a Transformed Deer Cell Line Infected with Chronic Wasting Disease - Raymond, et al.
Journal of Virology - January 2006
Detection and Localization of PrPSc in the Skeletal Muscle of Patients with Variant, Iatrogenic, and Sporadic Forms of Creutzfeldt-Jakob Disease - Peden, et al.
American Journal of Pathology - 2006 (abstract)
Abnormal Prion Protein in Ectopic Lymphoid Tissue in a Kidney of an Asymptomatic White-tailed Deer Experimentally Inoculated with the Agent of Chronic Wasting Disease - Hamir, et al.
Veterinary Pathology - 2006 (abstract)
Variant CJD (vCJD) and Bovine Spongiform Encephalopathy (BSE): 10 and 20 years on: part 1 - Bradley, et al.
Folia Neuropathologica - 2006 (pdf)
Variant CJD (vCJD) and Bovine Spongiform Encephalopathy (BSE): 10 and 20 years on: part 2 - Collee, et al.
Folia Neuropathologica - 2006 (pdf)
WHO guidelines on tissue infectivity distribution in transmissible spongiform encephalopathies
World Health Organization - 2006 (pdf)
Alzheimer-type neuropathology in a 28 year old patient with iatrogenic Creutzfeldt-Jakob disease after dural grafting - Preusser et al.
Journal of Neurology, Neurosurgery, and Psychiatry - 2006 (abstract)
Chronic Wasting Disease of Elk and Deer and Creutzfeldt-Jakob Disease: Comparative Analysis of the Scrapie Prion Protein - Xie, et al.
(Pre-publication copy) - 2006 (pdf)
First and Second Cattle Passage of Transmissible Mink Encephalopathy by Intracerebral Inoculation - Hamir, et al.
Veterinary Pathology - 2006 (abstract)
Experimental Second Passage of Chronic Wasting Disease (Cwd-Mule Deer) Agent to Cattle - Hamir, et al.
Journal Of Comparative Pathology - 2006 (pdf)
Interspecies Transmission of Chronic Wasting Disease Prions to Squirrel Monkeys (Saimiri sciureus) - Marsh, et al.
Journal of Virology - November 2005 (pdf)
A newly identified type of scrapie agent can naturally infect sheep with resistant PrP genotypes - Le Dur, et al.
Proceedings of the National Academy of Sciences - October 20, 2005 (pdf)
Coincident Scrapie Infection and Nephritis Lead to Urinary Prion Excretion - Seeger, et al.
Science - October 14, 2005 (abstract)
Creutzfeldt-Jakob Disease Surveillance and Diagnosis - Belay, et al.
Clinical Infectious Diseases - September 15, 2005 (pdf)
The most infectious prion protein particles - Silveira, et al.
Nature - September 8, 2005 (abstract)
Extraneural Prion Neuroinvasion without Lymphoreticular System Infection - Bartz, et al.
Journal of Virology - September 2005 (pdf)
Chronic Wasting Disease of Elk: Transmissibility to Humans Examined by Transgenic Mouse Models - Kong, et al.
The Journal of Neuroscience - August 31, 2005 (pdf)
Detection of prions in blood - Castilla, et al.
Nature Medicine - August 28, 2005 (abstract)
Natural transmission of BSE between sheep within an experimental flock - Bellworthy, et al.
Veterinary Record - August 13, 2005 (abstract)
Prion Infection of Mucosal Tissue - Bessen, et al.
2nd International Chronic Wasting Disease Symposium- July 12, 2005
RELATIVE VULNERABILITY OF CHRONIC WASTING DISEASE INFECTED MULE DEER TO VEHICLE COLLISIONS - Krumm, et al.
Journal of Wildlife Diseases - July 2005 (pdf)
Low frequency of PrP genotype 225SF among free-ranging mule deer (Odocoileus hemionus) with chronic wasting
disease - Jewell, et al.
Journal of General Virology - May 27, 2005 (pdf)
Brain biopsy in dementia - Warren, et al.
Brain - A journal of Neurology - May 18, 2005 (abstract)
Experimental transmission of chronic wasting disease agent from mule deer to cattle by the intracerebral route - Hamir, et al.
Journal of Veterinary Diagnostic Investigation - May 2005 (abstract)
Risk of oral infection with bovine spongiform encephalopathy agent in primates - Lasmézas, et al.
Lancet - February 26, 2005 (abstract)
Additional Cases of Chronic Wasting Disease in Imported Deer in Korea - Kim, et al.
Risks of transmission of variant Creutzfeldt-Jakob disease by blood transfusion - Peden, et al.
Folia Neuropathologica - 2005 (pdf)
Chronic Wasting Disease - Williams
Veterinary Pathology - 2005 (pdf)
Epidemiology of chronic wasting disease in free-ranging mule deer: spatial, temporal, and demographic influences on observed prevalence patterns - Miller and Conner
Journal of Wildlife Diseases - 2005
Protease-Resistant Human Prion Protein and Ferritin Are Cotransported across Caco-2 Epithelial Cells: Implications for Species Barrier in Prion Uptake from the Intestine - Mishra, et al.
The Journal of Neuroscience - December 15, 2004 (pdf)
Pathology of Variant CreutzfeIdt-Jakob Disease - Ironside
International Symposium of Prion Diseases, Sendai, Japan - October 31 - November 2, 2004
A Fresh Look at BSE - Chesebro
Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient - Peden, et al.
Lancet - August 7, 2004 (abstract)
Prion Infection of Skeletal Muscle Cells and Papillae in the Tongue - Mulcahy, et al.
Journal of Virology - July 2004
Bovine spongiform encephalopathy infectivity in greater kudu (Tragelaphus strepsiceros) - Cunningham, et al.
Emerging Infectious Diseases - June 2004 (abstract)
Environmental Sources of Prion Transmission in Mule Deer - Miller, et al.
Emerging Infectious Diseases - June 2004 (pdf)
Chronic Wasting Disease and Potential Transmission to Humans - Belay, et al.
Emerging Infectious Diseases - June 2004 (pdf)
Inactivation of Transmissible Spongiform Encephalopathy (Prion) Agents by Environ LpH - Race and Raymond
Journal of Virology - February 2004 (pdf)
Identification of a second bovine amyloidotic spongiform encephalopathy: Molecular similarities with sporadic Creutzfeldt-Jakob disease - Casalone, et al.
Proceedings of the National Academy of Sciences - March 2, 2004 (pdf)
Best Management Practices for Handling Suspect Biosafety Level 2 Animal Transmissible Spongiform Encephalopathy (TSE) Diagnostic Samples (Scrapie, Chronic Wasting Disease and Transmissible Mink Encephalopathy) in Animal Health Laboratories
American Association of Veterinary Laboratory Diagnosticians - February 18, 2004
Atypical Case of Bovine Spongiform Encephalopathy in an East-Flemish Cow in Belgium - De Bosschere, et al.
The International Journal of Applied Research in Veterinary Medicine - 2004
Characterization of two distinct prion strains derived from bovine spongiform encephalopathy transmissions to inbred mice - Lloyd, et al.
Journal of General Virology - 2004 (pdf)
Novel methods for disinfection of prion-contaminated medical devices - Fichet, et al.
Polymorphisms in the prion precursor functional gene but not the pseudogene
are associated with susceptibility to chronic wasting disease in
white-tailed deer -
Journal of General Virology - 2004 (pdf)
Prion Diseases: from transmission experiments to structural biology — still searching for the cause - Liberski & Brown
Folia Neuropathologica - 2004 (pdf)
Creutzfeldt-Jakob disease and inclusion body myositis: Abundant disease-associated prion protein in muscle - Kovacs, et al.
Annals of Neurology - December 30, 2003 (abstract)
Horizontal prion transmission in mule deer - Miller & Williams
The gathering of deer during winter may foster the spread of chronic wasting disease.
Nature - September 4, 2003 (pdf)
Cases of scrapie with unusual features in Norway and designation of a new type, Nor98 - Benestad, et al.
The Veterinary Record - August 16, 2003 (abstract)
Abundant PrP(CWD) in tonsil from mule deer with preclinical chronic wasting disease - O'Rourke, et al.
Journal of Veterinary Diagnostic Investigation - July 2003 (abstract)
Transmissible Encephalopathies: Speculations and Realities - Manuelidis
Viral Immunology - June 2003 (abstract)
Ultra-high-pressure inactivation of prion infectivity in processed meat: A practical method to prevent human infection - Brown, et al.
Proceedings of the National Academy of Sciences - May 13, 2003 (pdf)
Discharges of Laboratory Waste to Publicly-Owned Treatment Works (POTWs) - DRAFT
Industrial Pretreatment Program - US Environmental Protection Agency Region 8 - May 4, 2003 (pdf)
FINAL OPINION AND REPORT ON : A TREATMENT OF ANIMAL WASTE BY MEANS OF HIGH TEMPERATURE (150°C, 3 HOURS) AND HIGH PRESSURE ALKALINE HYDROLYSIS.
European Commission - Scientific Steering Committee - April 10, 2003 (pdf)
Analysis of unusual accumulation of Creutzfeldt-Jakob disease cases in Orava and Liptov regions (northern Slovak focus) 1983-2000 - Mad'ar, et al.
Central European Journal of Public Health - March 2003 (abstract)
Fatal Degenerative Neurologic Illnesses in Men Who Participated in Wild Game Feasts --- Wisconsin, 2002
Centers for Disease Control and Prevention - February 21, 2003
Opinion on the use of small incinerators for BSE risk reduction
European Commission - Scientific Steering Committee - January 16-17, 2003 (pdf)
Atypical Proteinase K-Resistant Prion Protein (PrPres) Observed in an Apparently Healthy 23-Month-Old Holstein Steer -
Yamakawa, et al.
Japanese Journal of Infectious Diseases - 2003 (pdf)
Subclinical prion infection in humans and animals - Hill and Collinge
British Medical Bulletin - 2003 (abstract)
Chronic wasting disease in deer and elk: a critique of current models and their application - Schauber & Woolf
Wildlife Society Bulletin - 2003 (pdf)
Chronic Wasting Disease in Deer and Elk: Scientific Facts and Findings - Salman
Journal of Veterinary Medical Science - 2003 (pdf)
Chronic wasting disease and tissues that might carry a risk for human food and animal feed chains
European Commission - Scientific Steering Committee - 2003 (pdf)
Laboratory Security and Emergency Response Guidance for Laboratories Working with Select Agents
Centers for Disease Control and Prevention - December 6, 2002 (pdf)
Comparison of Abnormal Prion Protein Glycoform Patterns from Transmissible Spongiform Encephalopathy Agent-Infected Deer, Elk, Sheep, and Cattle - Race, et al.
Journal of Virology - December 2002 (pdf)
Bovine spongiform encephalopathy, chronic wasting disease, scrapie, and the threat to humans from prion disease epizootics - Bosque
Current neurology and neuroscience reports - November 2002 (abstract)
Contaminated dental instruments - Smith, et al.
Journal of Hospital Infection - July 2002 (abstract)
Characterization of Thermodynamic Diversity between Transmissible Spongiform Encephalopathy Agent Strains and Its Theoretical Implications - Somerville, et al.
Journal of Biological Chemistry - March 29, 2002 (pdf)
Prions in skeletal muscle - Bosque, et al.
Proceedings of the National Academy of Sciences - March 19, 2002 (pdf)
Inactivation of the BSE agent - Taylor
Comptes rendus biologies - January 2002 (abstract)
BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein - Asante, et al.
Thermostability of mouse-passaged BSE and scrapie is independent of host PrP genotype implications for the nature of the causal
agents - Taylor, et al.
Journal of General Virology - 2002 (pdf)
Subclinical Scrapie Infection in a Resistant Species: Persistence, Replication, and Adaptation of Infectivity during Four Passages - Race, et al.
The Journal of Infectious Diseases - 2002 (pdf)
Long-Term Subclinical Carrier State Precedes Scrapie Replication and Adaptation in a Resistant Species: Analogies to Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease in Humans - Race, et al.
Journal of Virology - November 2001 (pdf)
Creutzfeldt-Jakob Disease in Unusually Young Patients Who Consumed Venison - Belay, et al.
Archives of Neurology - October 2001 (pdf)
A Protease Resistant PrP Isoform Is Present In Urine of Animals and Humans Affected with Prion Diseases - Shaked, et al.
Journal of Biological Chemistry - June 21, 2001 (pdf)
Adaptation of the bovine spongiform encephalopathy agent to primates and comparison with Creutzfeldt-Jakob disease: Implications for human health - Lasmezas, et al.
Proceedings of the National Academy of Sciences - March 27, 2001 (pdf)
Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease: Background, Evolution, and Current Concerns - Brown, et al.
Emerging Infectious Diseases - 2001 (pdf)
Chronic Wasting Disease in Mule Deer: Disease Dynamics and Control - Gross & Miller
Journal of Wildlife Management - 2001 (pdf)
Species-barrier-independent prion replication in apparently resistant species - Hill, et al.
Proceedings of the National Academy of Sciences - August 29, 2000 (pdf)
Transmission of prion diseases by blood transfusion - Hunter, et al.
Journal of General Virology - July 16, 2000 (pdf)
New studies on the heat resistance of hamster-adapted scrapie agent: Threshold survival after ashing at 600°C suggests an inorganic template of replication - Brown, et al.
Proceedings of the National Academy of Sciences - March 28, 2000 (pdf)
Evidence of a molecular barrier limiting susceptibility of humans, cattle and sheep to chronic wasting disease - Raymond, et al.
Inactivation of Transmissible Degenerative Encephalopathy Agents: A Review - D.M. Taylor
Veterinary Journal - 2000 (pdf)
Transmission of BSE by blood transfusion in sheep - Houston, et al.
Biosafety in Microbiological and Biomedical Laboratories - Fourth Edition
Inactivation of prions by physical and chemical means - Taylor
Journal of Hospital Infection - December 1999 (abstract)
Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus) -
Sigurdson, et al.
Journal of General Virology - 1999 (pdf)
Use of capillary electrophoresis and fluorescent labeled peptides to detect the abnormal prion protein in the blood of animals that are infected with a transmissible spongiform encephalopathy - Schmerr, et al.
Journal of Chromatography - 1999 (abstract)
The Host Range of Chronic Wasting Disease Is Altered on Passage in Ferrets - Bartz, et al.
Prions - Prusiner (Nobel Lecture)
Proceedings of the National Academy of Sciences - November 10, 1998 (pdf)
BSE: the final resting place - Brown
Scrapie Infectivity and Proteinase K–Resistant Prion Protein in Sheep Placenta, Brain, Spleen, and Lymph Node: Implications for Transmission and Antemortem Diagnosis - Race, et al.
The Journal of Infectious Diseases - 1998 (pdf)
Inactivation of the 22A strain of scrapie agent by autoclaving in sodium hydroxide - Taylor, et al.
Veterinary Microbiology - November 1997 (abstract)
Epidemiological observations on spongiform encephalopathies in captive wild animals in the British Isles - Kirkwood & Cunningham
The Veterinary Record - September 24, 1994 (abstract)
Transmission of Creutzfeldt-Jakob disease to a chimpanzee by electrodes contaminated during neurosurgery - Gibbs, et al.
Journal of neurology, neurosurgery, and psychiatry - June 1994
Intracerebral transmission of scrapie to cattle - Cutlip, et al.
Journal of Infectious Diseases - April 1994 (pdf)
Decontamination studies with the agents of bovine spongiform encephalopathy and scrapie - Taylor, et al.
Archives of Virology - 1994 (abstract)
Comparative Analysis of Scrapie Agent Inactivation Methods - Ernst and Race
Journal of Virological Methods - 1993 (pdf)
The coexistence of Alzheimer's disease and Creutzfeldt-Jakob disease in a patient with dementia of long duration - Muramoto, et al.
Acta Neuropathologica - 1992 (pdf)
"Clusters" of CJD in Slovakia: the first laboratory evidence of scrapie - Mitrova, et al.
European Journal of Epidemiology - September 1991
Survival of scrapie virus after 3 years' interment - Brown & Gajdusek
Lancet - February 2, 1991 (abstract)
Concomitant Creutzfeldt-Jakob and Alzheimer diseases - Powers, et al.
Acta Neuropathologica - 1991 (pdf)
Coexistence of Creutzfeldt-Jakob disease and Alzheimer's disease in the same patient - Brown, et al.
Neurology - February 1990 (abstract)
Evidence That Transmissible Mink Encephalopathy Results from Feeding Infected Cattle - Marsh & Hartsough
Amyloid plaques in spongiform encephalopathy of mule deer - Bahmanyar, et al.
Journal of Comparative Pathology - January 1985
Sheep consumption: a possible source of spongiform encephalopathy in humans - Davanipour, et al.
Virus-Like Sensitivity of the Scrapie Agent to Heat Inactivation - Rohwer
Disinfection studies with two strains of mouse-passaged scrapie agent. Guidelines for Creutzfeldt-Jakob and related agents - Kimberlin,
et al.
Journal of the Neurological Sciences - June 1983 (abstract)
Effect of chemicals, heat, and histopathologic processing on high-infectivity hamster-adapted scrapie virus - Brown, et al.
Journal of Infectious Diseases - May 1982 (abstract)
Oral transmission of kuru, Creutzfeldt-Jakob disease, and scrapie to nonhuman primates - Gibbs, et al.
Journal of Infectious Diseases - August 1980 (abstract)
UNCONVENTIONAL VIRUSES AND THE ORIGIN AND DISAPPEARANCE OF KURU - Gajdusek