-
|
Lancet. 2004 Aug
7-13;364(9433):527-9. |
|
-
Comment in:
Preclinical vCJD after
blood transfusion in a PRNP codon 129 heterozygous
patient.
Peden AH,
Head MW,
Ritchie DL,
Bell JE,
Ironside JW.
National Creutzfeldt-Jakob Disease Surveillance Unit,
Division of Pathology, School of Molecular and Clinical
Medicine, University of Edinburgh, Western General
Hospital, Edinburgh EH4 2XU, UK.
We report a case of preclinical variant
Creutzfeldt-Jakob disease (vCJD) in a patient who died
from a non-neurological disorder 5 years after receiving
a blood transfusion from a donor who subsequently
developed vCJD. Protease-resistant prion protein
(PrP(res)) was detected by western blot,
paraffin-embedded tissue blot, and immunohistochemistry
in the spleen, but not in the brain.
Immunohistochemistry for prion protein was also positive
in a cervical lymph node. The patient was a heterozygote
at codon 129 of PRNP, suggesting that susceptibility to
vCJD infection is not confined to the methionine
homozygous PRNP genotype. These findings have major
implications for future estimates and surveillance of
vCJD in the UK.
PMID: 15302196 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=15302196
|