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Coexistence of
Creutzfeldt-Jakob disease and Alzheimer's
disease in the same patient.
- Brown P,
- Jannotta F,
- Gibbs CJ Jr,
- Baron H,
- Guiroy DC,
- Gajdusek DC.
Laboratory of CNS
Studies, NINDS, National Institutes of Health,
Bethesda, MD 20892.
We report the case of a 73-year-old patient in
whom a diagnosis of Creutzfeldt-Jakob disease,
suggested by the clinical course, was verified
by the neuropathologic finding of widespread
spongiform change and astrogliosis, the presence
of proteinase-resistant protein in brain
extracts, and the experimental transmission of
spongiform encephalopathy to primates inoculated
with brain tissue. However, neuropathologic
examination also revealed a profusion of senile
and neuritic plaques and neurofibrillary tangles
that reacted with antibody to the amyloid
beta-protein characteristic of Alzheimer's
disease, but not with antibody to the scrapie
amyloid protein characteristic of
Creutzfeldt-Jakob disease.
PMID: 2405293 [PubMed - indexed for MEDLINE]