Journal of Comparative Pathology
Volume 95, Issue 1 , January 1985, Pages 1-5
* Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, U.S.A.
† Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, U.S.A.
‡ Department of Chemical Pathology, Armed Forces Institute of Pathology, Washington, D.C., U.S.A.
Received 25 May 1983. Available online 10 February 2004.
Volume 95, Issue 1 , January 1985, Pages 1-5
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Amyloid plaques in spongiform encephalopathy of mule deer
S. Bahmanyar*, E. S. Williams†, F. B. Johnson‡, S. Young† and D. C. Gajdusek*
* Laboratory of Central Nervous System Studies, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, U.S.A.
† Department of Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, U.S.A.
‡ Department of Chemical Pathology, Armed Forces Institute of Pathology, Washington, D.C., U.S.A.
Received 25 May 1983. Available online 10 February 2004.
Abstract
Amyloid plaques were demonstrable in central nervous system tissues of adult captive mule deer affected with chronic wasting disease, a transmissible primary spongiform encephalopathy. Plaques were detected in tissues of 13 of 21 (62 per cent) spontaneously affected animals from 2 to 4 years of age or older, but were not found in 16 unaffected deer of from a few months to 12 years of age